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  • Leucovorin Teva Tablets
    / Teva


    Active Ingredient

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Tablets

    10 X 15 mg

    full basket chart 7799 12257

    Related information


    Dosage

    For oral administration
    Calcium Folinate Rescue: Adults and Children: In general up to 120 mg in divided doses over 12 – 24 hours by intramuscular injection, bolus intravenous injection, or intravenous infusion in 0.9% w/v sodium chloride solution followed by 12 – 15mg intramuscularly or 15mg orally, every six hours for the next 48 hours.
    Leucovorin teva should not be given simultaneously with methotrexate as it may reduce or suppress its anti-neoplastic activity. It is recommended that administration should commence within the first 24 hours following methotrexate. In overdose situations or when the half-life of methotrexate is increased (e.g. renal function impairment or pleural or peritoneal effusions) it is important that Leucovorin teva be given until the blood concentration of methotrexate declines to non-toxic concentrations. In these cases, doses of Leucovorin teva equal to or greater than those of methotrexate should be given.
    Folinate deficiency: Adults: 15 mg (one tablet) per day
    Children up to 12 years: 0.25 mg/kg/day


    Indications

    Counteracts the action of folic acid antagonists.
    Improves blood picture in megaloblastic anemias due to folate deficiency.


    Contra-Indications

    Known hypersensitivity to the preparation.


    Special Precautions

    High dose methotrexate therapy together with leucovorin rescue should only be carried out under the direction of physicians experienced in antitumour chemotherapy.
    Leucovorin teva should not be used in the treatment of pernicious anaemia or
    megaloblastic anaemias due to the lack of where vitamin B12 is deficient.
    Lactose: Leucovorin teva tablets contains the ingredient, lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.


    Side Effects

    Allergic sensitization including anaphylactoid reactions and urticaria has been
    reported.
    Adverse reactions to calcium folinate are rare, but following intravenous or
    intramuscular administration, occasional pyrexial reactions have been reported.


    Drug interactions

    Potential interactions between folinic acid and antiepileptics may occur; the plasma concentrations of phenobarbital, phenytoin and primidone may possibly be reduced, increasing the frequency of seizures in susceptible patients.


    Pregnancy and Lactation

    Caution should be exercised in pregnancy and lactation.


    Overdose

    No special intructions.


    Manufacturer
    Teva Pharmaceutical Industries Ltd, Israel
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