All the Active Ingredient Drugs
Penicillin, β Lactamase Inhibitors. Piperacillin Sodium 4 gr, Tazobactam (as sodium) 500 mg. VIALS (pwder. for I.V. infus.): 10. Slow I.V.
infus. every 6-12 hrs depend. on
severity of cond. See lit.
Systemic and/or local bacterial infects.
caused by suscept. organisms.
C/I: Known hypersens. See lit.
Penicillin, β Lactamase Inhibitors. Piperacillin Sodium 2 g, 4 g, Tazobactam (as sodium salt) 0.25 g, 0.5 g. VIAL ( pwdr. for sol. for infus.): 1, 5, 10×15, 50ml (2g/0.25 g). 1, 5, 10× 50ml (4g/0.5 g). Adult., adolesc.> 12 yrs. 4 g piperacillin / 0.5 g tazobactam given every 8 hrs. For nosoc. pneum., bact. infec. in neutr. pts., the recom. dose is 4 g / 0.5 admin. every 6 hrs. Nosoc. Pneum. Init. presum. tmt. of pts. with nosoc. pneum. start. dose 4 / 0.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). See lit.
Tmt. of syst. and/or local infec. caused by suscept. organis. In comb. with an aminoglycoside – tmt. of suspected bact. infec. in neutrop. adults and child. above 2 yrs. Appendicitis compl.by rupture with peritonitis and/or abscess formation in child. aged 2-12 yrs. Tmt. of the follow. infec. in adults and adolesc.: Severe pneumonia includ. hospital-acquired and ventilator-assoc.pneumonia. Compl. UTI (includ. pyelonephritis), Compl. intra-abd.infec. Compl. skin and soft tissue infec (include.diabetic foot infec.) Manag. of neutropenic pts. with fever suspected to be due to a bact. infec. Acts Synerg. with aminoglycosides against certain strains of Pseudomonas aeruginosa. Tmt. of develop. of drug-resis. bacteria and maint. the effective. of Piperacillin/Tazobactam - and other antibact. drugs.
C/I: Hist. of allerg. reac. to any of the penicillins, cephalosporins, β-lactam act. subst., (e.g. monobactam or carbapenem) or β-lactamase inhib. Hypersens. to the act. subst. or to any of IV solvent.
Other Cephalosporins & Penems. Ceftolozane 1 g, Tazobactam 0.5 g. VIAL (Pwdr. for concentrate for sol. for infus.): 10. The recomm. IV dose regimen for pts. with CrCl>50 mL/min.
Complicated intra-abdom. infec.*: 1 g ceftolozane/0.5 g tazobactam (To be used in comb. with metronidazole when anaerobic pathogens are suspected.) every 8 hrs., Infus. time 1 h, duration of the tmt. 4-14 days.
Complicated UTI's, acute pyelonephritis: 1 g ceftolozane/0.5 g tazobactam, every 8 hrs., infus. time 1h, 7 days.
Complic. intra-abdom. infec.
Acute pyelonephritis caused by pathogens resist. to other tmts. as confirmed by urine culture.
Consid. should be given to official guidance on the appropriate use of antibact. agents.
C/I: Hypersens. Hypersens. to any cephalosporin antibact. agent.
Severe hypersens. (e.g., anaphylactic reaction, severe skin reaction) to any other type of beta-lactam antibact. agent (e.g., penicillins or carbapenems).