All the Active Ingredient Drugs
Colony Stimulating Factor. Filgrastim 30 MU/ml (0.3 mg/ml), 30 MU/0.5 ml (0.6 mg/ml), 48 MU/0.5 ml (0.96 mg/ml). VIALS (sol. for inj.): 5×30MU (0.3 mg/
PREF. SYR. (sol. for inj.): 5×30MU (0.6 mg/
ml), 1, 5×48MU (0.96 mg/ml). Dosage ajust. individ. accord. pt. med. condition.
Reduct. in the duration of neutropenia and
the incidence of febrile neutropenia in pts.
treated with established cytotoxic
chemother. for malign. (with the exception
of chronic myeloid leukaemia and
myelodysplastic syndr.) and for the reduct.
in the duration of neutropenia in pts.
undergoing myeloablative ther. followed
by bone marrow transplant., considered
to be at incr. risk of prolon. severe
neutropenia. The safety and efficacy of
Filgrastim are similar in adults and child.
receiving cytotoxic chemother. Indic. for
the mobilisation of peripheral blood
progenitor cells (PBPCs). In pts., children/
adults, with severe congen., cyclic or
idiopathic neutropenia with an ANC of
≤0.5 ×10^9/l, and a history of severe or
recurrent infec., long-term admin. of this
drug is indicated to increase neutrophil
counts and to reduce the incidence and
duration of infect.-related events.
Colony Stimulating Factor. Filgrastim 0.6 mg/ml. PREFILLED SYRINGE: 1, 5, 10 x 30
MIU/0.5 ml, 48 MIU/0.8 ml.
0.5 MIU (5 μg)-1.2 MIU (12μg)/kg dly.
Reduct. durat. neutropen., febrile
neutropen. in pts. treated with establish.
cytotoxic chemother. for malign. (except
chron. myeloid leukem., myelodysplast.
syndr.); reduct. durat. neutropen. in
myeloablat. ther. foll. by bone marrow
transplant. at incr. risk of prolong. Severe
neutropen. For mobilisat. periph. Blood
progenitor cells in normal donors. Long
term admin. to incr. neutrophil counts
and reduce incidence and durat. of
infect.-relat. events in pts. with severe congen., cyclic, or idiopath. neutropen. with absolute neutrophil count (ANC) of 0.5 x 10^9/l and history of severe or recurr. infects. Tmt. persist. neutropen, (ANC < 1.0 x 10^9/l) in advanced HIV infect., to reduce risk of bact. infect. when other options inapprop.
C/I: Known hypersens.